Salmanoglu E, Kurutas EB. Effects of 99mTc-MDP bone scintigraphy on oxidative/nitrosative stress biomarkers in patients.Case Study Case Rep. 2017; 7(3): 65 – 75.
ABSTRACT
We aimed to define the effects of
Technetium-99m Methylendiphosphonate
bone scintigraphy on
oxidative/nitrosative stress in patients after intravenous injection and
compared to healthy control group. Forty
patients for bone scintigraphy and forty healthy control group were included
this study. The age range was similar in both groups (18-74 years). The blood
samples were taken from patients 2 hour
after intravenous injection of 20 mCi (740 MBq) Technetium-99m Methylendiphosphonate.
The activities of catalase, superoxide dismutase and malondialdeyhde levels
were measured as oxidative stress biomarkers and nitric oxide and nitrotyrosine levels were measured as nitrosative stress biomarkers in patients and control
group. There were no significant differences according to both age and sex
between two groups (p˃0.05). Activities of catalase and superoxide enzymes and
malondialdeyhde levels in patients were increased in patients compared to
controls (p<0.05). Also, nitric oxide
and nitrotyrosine levels in patients were higher than control group
(p<0.05). Technetium-99m Methylendiphosphonate may cause both oxidative and nitrosative
stress in patients. Also antioxidant defense of the patients was higher
compared to healthy subjects possibly due to a compensatory response to
ionising radiation in the living cells and thereby protects the cells against
oxidative/nitrosative damage.
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