OXIDATIVE STRESS IN PEDIATRIC PATIENTS WITH ACUTE HEPAITTIS A
Güler S, Kuratas EB, Ozden DS, Taner SS. Oxidative Stress in pediatric patients with acute hepatitis A. Case Study Case Rep. 2017; 7(4): 101 - 109.
ABSTRACT
We aimed to investigate the effect of oxidative stress, taking place in the pathogenesis of
many diseases, in patients with hepatitis A by evaluating the levels of malondialdehyde
(MDA) and Arylesterase (AREase) together. Patients with acute hepatitis A (n = 22) and
age- and sex-matched healthy group as controls (n = 30) were enrolled in this study.
Oxidative stress indicator such as AREase and MDA were studied in serum samples by the
method of ELISA and spectrophotometric, respectively. There was a statistically significant
difference between patients and controls for all parameters (P< 0.05). Malondialdehyde was
significantly elevated (P< 0.001), while AREase were significantly decreased (all P< 0.001)
in patients compared to healthy subjects. Our study shows that elevated MDA levels and
decreased AREase activity in patients with acute Hepatitis A may be indicating an oxidative
damage. Therapeutic strategies focused on decreasing oxidative stress may be used in the
management of the disease.
Keywords: Antioxidant, Oxidative stress, Hepatitis A
